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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PRKCI
All Species:
15.15
Human Site:
S222
Identified Species:
23.81
UniProt:
P41743
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.14
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P41743
NP_002731.4
596
68262
S222
T
V
I
P
Y
N
P
S
S
H
E
S
L
D
Q
Chimpanzee
Pan troglodytes
XP_001148501
597
67369
K225
A
Y
I
S
S
S
R
K
H
D
S
I
K
D
D
Rhesus Macaque
Macaca mulatta
XP_001089400
597
68263
S223
T
V
I
P
Y
N
P
S
S
H
E
S
L
D
Q
Dog
Lupus familis
XP_535855
696
78257
S322
T
V
I
P
Y
N
P
S
S
H
E
S
L
D
Q
Cat
Felis silvestris
Mouse
Mus musculus
Q62074
595
68185
S221
T
V
I
P
Y
N
P
S
S
H
E
S
L
D
Q
Rat
Rattus norvegicus
P09217
592
67715
I212
P
S
E
E
T
D
G
I
A
Y
I
S
S
S
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506164
360
41199
G25
F
D
L
L
R
V
I
G
R
G
S
Y
A
K
V
Chicken
Gallus gallus
XP_417561
606
69931
I226
P
S
E
E
N
D
G
I
P
Y
I
P
S
N
R
Frog
Xenopus laevis
NP_001084068
588
67442
R214
P
E
L
P
Y
R
P
R
S
Q
D
N
L
D
Q
Zebra Danio
Brachydanio rerio
Q90XF2
588
67303
N214
D
Q
V
L
G
K
K
N
S
T
E
S
I
N
H
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P13678
634
71138
A261
A
L
S
V
D
S
L
A
T
S
T
T
T
M
T
Honey Bee
Apis mellifera
XP_397273
590
68031
Q209
Q
Q
Q
L
D
S
V
Q
C
S
P
V
A
H
L
Nematode Worm
Caenorhab. elegans
Q19266
597
68017
I214
T
T
R
S
G
G
G
I
D
N
G
A
F
H
E
Sea Urchin
Strong. purpuratus
XP_780275
524
59689
G189
F
E
L
L
R
V
I
G
R
G
S
Y
A
K
V
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
P87253
1142
127954
S631
Q
A
S
T
Y
S
G
S
T
A
Y
T
S
I
A
Conservation
Percent
Protein Identity:
100
66.6
96.8
84.3
N.A.
98.3
72.3
N.A.
59.9
71.4
89.7
88.7
N.A.
36.4
67.9
58.1
63.5
Protein Similarity:
100
78.5
97.4
84.9
N.A.
98.8
83.5
N.A.
60.4
83
94.4
92.9
N.A.
54
78.1
74.1
72.4
P-Site Identity:
100
13.3
100
100
N.A.
100
6.6
N.A.
0
0
46.6
20
N.A.
0
0
6.6
0
P-Site Similarity:
100
20
100
100
N.A.
100
33.3
N.A.
6.6
26.6
66.6
46.6
N.A.
33.3
6.6
26.6
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
23.9
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
35.7
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
13.3
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
33.3
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
14
7
0
0
0
0
0
7
7
7
0
7
20
0
7
% A
% Cys:
0
0
0
0
0
0
0
0
7
0
0
0
0
0
0
% C
% Asp:
7
7
0
0
14
14
0
0
7
7
7
0
0
40
7
% D
% Glu:
0
14
14
14
0
0
0
0
0
0
34
0
0
0
7
% E
% Phe:
14
0
0
0
0
0
0
0
0
0
0
0
7
0
0
% F
% Gly:
0
0
0
0
14
7
27
14
0
14
7
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
7
27
0
0
0
14
7
% H
% Ile:
0
0
34
0
0
0
14
20
0
0
14
7
7
7
0
% I
% Lys:
0
0
0
0
0
7
7
7
0
0
0
0
7
14
0
% K
% Leu:
0
7
20
27
0
0
7
0
0
0
0
0
34
0
7
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
7
0
% M
% Asn:
0
0
0
0
7
27
0
7
0
7
0
7
0
14
0
% N
% Pro:
20
0
0
34
0
0
34
0
7
0
7
7
0
0
0
% P
% Gln:
14
14
7
0
0
0
0
7
0
7
0
0
0
0
34
% Q
% Arg:
0
0
7
0
14
7
7
7
14
0
0
0
0
0
14
% R
% Ser:
0
14
14
14
7
27
0
34
40
14
20
40
20
7
0
% S
% Thr:
34
7
0
7
7
0
0
0
14
7
7
14
7
0
7
% T
% Val:
0
27
7
7
0
14
7
0
0
0
0
7
0
0
14
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
7
0
0
40
0
0
0
0
14
7
14
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _